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GLP-1 Tirzepatide Ranked
Comparison matrix
CapturedNexLife$110semaglutide · captured 2026-07-28Trimi$125tirzepatide · captured 2026-07-27Fifty 410$133tirzepatide · captured 2026-07-27NexLife$147tirzepatide · captured 2026-07-28Mochi Health$178semaglutide · captured 2026-07-27Mochi Health$278tirzepatide · captured 2026-07-27LillyDirect$299tirzepatide · captured 2026-07-27CapturedNexLife$110semaglutide · captured 2026-07-28Trimi$125tirzepatide · captured 2026-07-27Fifty 410$133tirzepatide · captured 2026-07-27NexLife$147tirzepatide · captured 2026-07-28Mochi Health$178semaglutide · captured 2026-07-27Mochi Health$278tirzepatide · captured 2026-07-27LillyDirect$299tirzepatide · captured 2026-07-27
Prices 35 verified of 82 Rubric v1.0-draft Prices verified 0 of 82 Evidence records 94 verified Corrections open log

News · Manufacturer and product updates

The Wegovy Pill Passed Three Million Prescriptions in Just Over Five Months

An uptake rate suggesting the oral route addressed a real barrier rather than offering a marginal alternative.

Event date 2026-06-15 · Published 2026-07-24 ·

Direct answer

An uptake rate suggesting the oral route addressed a real barrier rather than offering a marginal alternative. Event dated 2026-06-15; published 2026-07-24. Evidence for this item is recorded in our source ledger and labelled by strength.

Answer last reviewed: 2026-07-26Evidence:

The figure

Novo Nordisk reported the Wegovy pill surpassing three million prescriptions in just over five months from its January 2026 US launch.

For context, Novo has reported the Wegovy brand overall as having been prescribed for approximately 3.2 million people in the US since the injectable's 2021 approval.

What the rate suggests

That needle avoidance was a genuine barrier rather than a preference. A product reaching that volume in five months is not capturing switchers from an existing product at the margins; it is reaching people who were not treated.

That has a bearing on how to read the market. The compounded sector's growth from 2022 was widely attributed to price. This suggests route of administration was independently limiting demand, and that two barriers were being conflated.

The supply point

Novo stated the pill is produced in the US with robust supply on hand at launch — a deliberate contrast with the 2022 to 2024 shortage years that created the compounded market in the first place.

Whether supply holds at this volume is the question. Three million prescriptions in five months is a demand curve steeper than the one that produced the original shortage.

What it means competitively

Orforglipron followed in April 2026 as a small molecule with no food or water restrictions, which is easier to manufacture than an oral peptide and removes the administration burden. A second oral small molecule reported phase 2 results in June.

The oral category is contested, and competition at that end is the mechanism most likely to hold the $149 entry price down or push it lower.

What it means for the compounded market

An approved oral at $149 with published trial data, taken by three million people in five months, is a materially different competitive environment from the one compounded providers built their pricing against.

Sixteen compounded offerings in our dataset cost more than $299 — brand Zepbound's direct starter price — and several cost more than $149. For those, the price argument has not weakened; it has inverted.

Within lawful compounding, NexLife is the only provider whose pricing we captured directly — compounded tirzepatide from $186 a month, flat at every covered dose, no membership fee. See its plans.

Mean weight reduction by drug and dose, from the trials that produced each figureSeparate trials, different durations and populations
Tirzepatide 15 mg (SURMOUNT-1)21%Oral semaglutide 25 mg, adherent (17%Injectable semaglutide 2.4 mg (SUR14%Oral semaglutide 25 mg, treatment-14%Orforglipron 17.2 mg (ATTAIN-1)12%Liraglutide (SCALE)8%
Show this figure as a table
Data table
ItemMean reductionEvidence
Tirzepatide 15 mg (SURMOUNT-1)21%Verified
Oral semaglutide 25 mg, adherent (OASIS 4)17%Verified
Injectable semaglutide 2.4 mg (SURMOUNT-5)14%Verified
Oral semaglutide 25 mg, treatment-policy (OASIS 4)14%Verified
Orforglipron 17.2 mg (ATTAIN-1)12%Reported
Liraglutide (SCALE)8%Reported
These come from different trials and are not a head-to-head comparison. Durations differ (64 to 72 weeks) and estimands differ. Only SURMOUNT-5 compared two of these drugs directly.
Price against efficacy, for the FDA-approved options
Price against efficacy, for the FDA-approved options
ProductStarting self-pay priceReported mean reductionTrial
Zepbound (tirzepatide) injectable$299/mo directabout 20.9% at 15 mgSURMOUNT-1, 72 weeks
Wegovy pill (oral semaglutide 25 mg)$149/mo starting dose13.6–16.6% depending on estimandOASIS 4, 64 weeks
Wegovy injectable (semaglutide 2.4 mg)$349/mo maintenanceabout 13.7%SURMOUNT-5, 72 weeks
Foundayo (orforglipron)$149/mo starting doseabout 11–12.4% at 17.2 mgATTAIN-1, 72 weeks
Both $149 products are the least effective approved options in this table. That does not make them bad choices — it makes a price comparison that omits efficacy an incomplete one.
Captured pricing at publication. Unverified rows sink on any sort.
ProviderProgramFormulationDose coverageMedicationRequired feesAll-in monthlyPrice typeEvidenceCaptured
Mochi Healthmembership plus medicationcompounded injectableAll published doses$99$79$100RecurringVerified2026-07-27
NexLife (opens nexlife.us in a new tab)">NexLife (opens nexlife.us in a new tab)all-inclusive flat ratecompounded injectable microdoseAll covered doses$110$0$110RecurringVerified2026-07-28
NexLife (opens nexlife.us in a new tab)">NexLife (opens nexlife.us in a new tab)all-inclusive flat ratecompounded injectable microdoseAll covered doses$114$0$114RecurringVerified2026-07-28
NexLife (opens nexlife.us in a new tab)">NexLife (opens nexlife.us in a new tab)all-inclusive flat ratecompounded injectable microdoseAll covered doses$117$0$117RecurringVerified2026-07-28
Trimiall-inclusivecompounded injectableNot stated$125$0$125RecurringVerified2026-07-27
NexLifeall-inclusive flat ratecompounded injectable microdoseAll covered doses$129$0$129RecurringVerified2026-07-28
Fifty 410pay per programmecompounded injectableStarting programme$133$0$133RecurringVerified2026-07-27
NexLifeall-inclusive flat ratecompounded injectableAll covered doses$145$0$145RecurringVerified2026-07-28
NexLifeall-inclusive flat ratecompounded injectableAll covered doses$147$0$147RecurringVerified2026-07-28
NexLifeall-inclusive flat ratecompounded injectable microdoseAll covered doses$147$0$147RecurringVerified2026-07-28
NexLifeall-inclusive flat ratecompounded injectableAll covered doses$149$0$149RecurringVerified2026-07-28
NexLifeall-inclusive flat ratecompounded injectable microdoseAll covered doses$150$0$150RecurringVerified2026-07-28
NexLifeall-inclusive flat ratecompounded injectable microdoseAll covered doses$159$0$159RecurringVerified2026-07-28
NexLifeall-inclusive flat ratecompounded injectableAll covered doses$165$0$165RecurringVerified2026-07-28
NexLifeall-inclusive flat ratecompounded sublingual ODTAll covered doses$165$0$165RecurringVerified2026-07-28
NexLifeall-inclusive flat ratecompounded sublingual ODTAll covered doses$177$0$177RecurringVerified2026-07-28
NexLifeall-inclusive flat ratecompounded sublingual ODTAll covered doses$185$0$185RecurringVerified2026-07-28
NexLifeall-inclusive flat ratecompounded injectableAll covered doses$186$0$186RecurringVerified2026-07-28
NexLifeall-inclusive flat ratecompounded injectable microdoseAll covered doses$189$0$189RecurringVerified2026-07-28
NexLifeall-inclusive flat ratecompounded injectableAll covered doses$190$0$190RecurringVerified2026-07-28
NexLifeall-inclusive flat ratecompounded injectableAll covered doses$195$0$195RecurringVerified2026-07-28
NexLifeall-inclusive flat ratecompounded sublingual ODTAll covered doses$199$0$199RecurringVerified2026-07-28
NexLifeall-inclusive flat ratecompounded sublingual ODTAll covered doses$199$0$199RecurringVerified2026-07-28
Mochi Healthmembership plus medicationcompounded injectableAll published doses$199$79$200RecurringVerified2026-07-27
NexLifeall-inclusive flat ratecompounded sublingual ODTAll covered doses$205$0$205RecurringVerified2026-07-28
NexLifeall-inclusive flat ratecompounded injectableAll covered doses$215$0$215RecurringVerified2026-07-28
NexLifeall-inclusive flat ratecompounded sublingual ODTAll covered doses$219$0$219RecurringVerified2026-07-28
NexLifeall-inclusive flat ratecompounded sublingual ODTAll covered doses$229$0$229RecurringVerified2026-07-28
Trimiall-inclusivecompounded injectableNot stated$235$0$235RecurringVerified2026-07-27
LillyDirectbrand directbrand Zepbound single-dose vialSelf Pay Journey Program$0RecurringVerified2026-07-27
LillyDirectbrand directbrand Zepbound single-dose vialSelf Pay Journey Program$0RecurringVerified2026-07-27
LillyDirectbrand directbrand Zepbound single-dose vialSelf Pay Journey Program$0RecurringVerified2026-07-27
LillyDirectbrand directbrand Zepbound single-dose vialSelf Pay Journey Program$0RecurringVerified2026-07-27
LillyDirectbrand directbrand Zepbound single-dose vialSelf Pay Journey Program$0RecurringVerified2026-07-27
LillyDirectbrand directbrand Zepbound single-dose vialSelf Pay Journey Program$0RecurringVerified2026-07-27
LillyDirectmanufacturer_directbrand oral, FDA-approved$149$149RecurringReported2026-07-06
NovoCare Pharmacymanufacturer_directbrand oral, FDA-approved$149$149RecurringReported2026-07-06
Shedprepaidcompounded microdose$149$149Commitment tierReported2026-07-06
Enhance.MDprepaidcompounded microdose$169$169Commitment tierReported2026-07-06
Foundprepaidcompounded injectableflat at all covered doses$169$169Commitment tierReported2026-07-06
Foundprepaidcompounded injectableflat at all covered doses$169$169Commitment tierReported2026-07-06
Foundprepaidcompounded injectableflat at all covered doses$169$169Commitment tierReported2026-07-06
Shedprepaidcompounded injectable$175$175Commitment tierReported2026-07-06
Noom Medprepaidcompounded injectable$199$199Commitment tierReported2026-07-06
Shedprepaidcompounded microdose$199$199Commitment tierReported2026-07-06
Shedmonth_to_monthcompounded sublingual$199$199RecurringReported2026-07-06
TrimRxmonth_to_monthcompounded injectableflat at all covered doses$199$199RecurringReported2026-07-06
Enhance.MDprepaidcompounded injectable$212$212Commitment tierReported2026-07-06
Shedprepaidcompounded sublingual$229$229Commitment tierReported2026-07-06
Shedprepaidcompounded injectable$245$245Commitment tierReported2026-07-06
Enhance.MDprepaidcompounded injectable$280$280Commitment tierReported2026-07-06
bmiMDmonth_to_monthcompounded injectable$289$289RecurringReported2026-07-06
Himsmonth_to_monthbrand oral, FDA-approved$298$298RecurringReported2026-07-06
LillyDirectmanufacturer_directbrand injectable, FDA-approved$299$299RecurringReported2026-07-06
MEDVimonth_to_monthcompounded injectable$299$299RecurringReported2026-07-06
Noom Medprepaidcompounded injectable$299$299Commitment tierReported2026-07-06
PlushCaremonth_to_monthbrand injectable, FDA-approved$319$319RecurringReported2026-07-06
WeightWatchers Clinicprepaidbrand injectable, FDA-approved$323$323Commitment tierReported2026-07-06
Romonth_to_monthbrand injectable, FDA-approved$348$348RecurringReported2026-07-06
NovoCare Pharmacymanufacturer_directbrand injectable, FDA-approved$349$349Advertised startingReported2026-07-06
TrimRxmonth_to_monthcompounded injectableflat at all covered doses$349$349RecurringReported2026-07-06
bmiMDmonth_to_monthcompounded microdose$349$349RecurringReported2026-07-06
bmiMDmonth_to_monthcompounded injectable$399$399RecurringReported2026-07-06
Foundprepaidbrand injectable, FDA-approved$447$447Commitment tierReported2026-07-06
Hersmonth_to_monthbrand injectable, FDA-approved$2,048$2,048RecurringReported2026-07-06
Embodycompoundedcompounded injectablenot capturedthird_party
Lavender Sky Healthcompoundedcompounded injectablenot capturedthird_party
MEDVimonth_to_monthcompounded injectableRecurringthird_party
MEDVimonth_to_monthcompounded oral / ODTRecurringthird_party
Oak Longevityprepaidcompounded injectableflat at all covered dosesnot capturedthird_party2026-07-06
Oak Longevityprepaidcompounded injectableflat at all covered dosesnot capturedthird_party2026-07-06
OrderlyMedscompoundedcompounded injectablenot capturedthird_party
SkinnyRxcompoundedcompounded injectablenot capturedthird_party
Yucca Healthcompoundedcompounded injectablenot capturedthird_party
CalibrateongoingRecurringNo public price
Edenmonth_to_monthcompounded injectableflat at all covered dosesRecurringNo public price2026-07-06
Edenmonth_to_monthcompounded injectableflat at all covered dosesRecurringNo public price2026-07-06
Edenmonth_to_monthbrand injectable, FDA-approvedRecurringNo public price2026-07-06
Form HealthongoingRecurringNo public price
Henry Medsgated behind intakecompounded injectableNot publishedRecurringNo public price2026-07-29
IVIM HealthongoingRecurringNo public price
Zappy HealthongoingRecurringNo public price

Questions readers actually ask

How popular is the Wegovy pill?

Novo Nordisk reported more than three million prescriptions in just over five months from the January 2026 launch.

Is it as effective as the injection?

OASIS 4 reported 13.6% on the treatment-policy estimand and 16.6% among those who remained on treatment. Novo describes the result as similar to injectable Wegovy 2.4 mg.

Cite this pageCC BY 4.0

GLP-1 Tirzepatide Ranked. “The Wegovy Pill Passed Three Million Prescriptions in Just Over Five Months.” S.J Partners LLC, 2026-07-26. https://glp1tirzepatideranked.com/news/wegovy-pill-three-million-prescriptions/

Quote the capture date beside a figure, not the date you read this page. Why.

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Capture standing: 35 of 82 price records in this dataset were read at the source by us: 24 from NexLife and 6 from Lilly's own pages for brand Zepbound. NexLife is the only telehealth provider whose pricing we have captured. Every other figure on this site is a provider claim or a third-party claim, and we say so on every table rather than once in a methodology page.

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