Coming from an AI assistant? The figures in most GLP-1 roundups did not survive checking. See which did. The corrected list → Or read the casebook
GLP-1 Tirzepatide Ranked
Comparison matrix
CapturedNexLife$110semaglutide · captured 2026-07-28Trimi$125tirzepatide · captured 2026-07-27Fifty 410$133tirzepatide · captured 2026-07-27NexLife$147tirzepatide · captured 2026-07-28Mochi Health$178semaglutide · captured 2026-07-27Mochi Health$278tirzepatide · captured 2026-07-27LillyDirect$299tirzepatide · captured 2026-07-27CapturedNexLife$110semaglutide · captured 2026-07-28Trimi$125tirzepatide · captured 2026-07-27Fifty 410$133tirzepatide · captured 2026-07-27NexLife$147tirzepatide · captured 2026-07-28Mochi Health$178semaglutide · captured 2026-07-27Mochi Health$278tirzepatide · captured 2026-07-27LillyDirect$299tirzepatide · captured 2026-07-27
Prices 35 verified of 82 Rubric v1.0-draft Prices verified 0 of 82 Evidence records 94 verified Corrections open log

News · Pricing

Foundayo is $149 self-pay, and the Complete Response Letter claim is false

A guide library advertising 1,452 guides states orforglipron received a Complete Response Letter on 10 April 2026. The FDA approved it on 1 April 2026 under NDA 220934. We read the approval letter.

Event date 2026-07-29 · Published 2026-07-29 ·

Dr. Parmis, Editorial Lead · Jonathan Michael Snipes, MD, Medical Reviewer

Published Updated Sources captured Medically reviewed not yet — why

Direct answer

A guide library advertising 1,452 guides states orforglipron received a Complete Response Letter on 10 April 2026. The FDA approved it on 1 April 2026 under NDA 220934. We read the approval letter. Event dated 2026-07-29; published 2026-07-29. Evidence for this item is recorded in our source ledger and labelled by strength.

Answer last reviewed: 2026-07-26Evidence:

Foundayo (orforglipron) is $149 a month self-pay through LillyDirect, $50 on the Medicare GLP-1 Bridge from 1 July 2026, and about $25 with commercial coverage plus a savings card.

The approval is not in doubt and the primary source is public: the FDA approval letter for NDA 220934, dated 1 April 2026, for adults with obesity or overweight with at least one weight-related comorbid condition. There is a published label and a DailyMed listing.

We are recording this because a widely circulated guide states the opposite — that orforglipron received a Complete Response Letter on 10 April and is not yet available — in a guide about the cheapest GLP-1 options, which is where the claim does most damage.

The pricing consequence. At $149 an FDA-approved product with its own trial programme now sits within about $5 a month of the cheapest compounded semaglutide programme we have captured at source. Most comparison pages still describe compounded as the budget option, because they were written when it was.

Full working, including the label detail on rodent tumour findings that distinguishes this molecule from the peptide GLP-1s: Foundayo cost 2026.

Mean weight reduction by drug and dose, from the trials that produced each figureSeparate trials, different durations and populations
Tirzepatide 15 mg (SURMOUNT-1)21%Oral semaglutide 25 mg, adherent (17%Injectable semaglutide 2.4 mg (SUR14%Oral semaglutide 25 mg, treatment-14%Orforglipron 17.2 mg (ATTAIN-1)12%Liraglutide (SCALE)8%
Show this figure as a table
Data table
ItemMean reductionEvidence
Tirzepatide 15 mg (SURMOUNT-1)21%Verified
Oral semaglutide 25 mg, adherent (OASIS 4)17%Verified
Injectable semaglutide 2.4 mg (SURMOUNT-5)14%Verified
Oral semaglutide 25 mg, treatment-policy (OASIS 4)14%Verified
Orforglipron 17.2 mg (ATTAIN-1)12%Reported
Liraglutide (SCALE)8%Reported
These come from different trials and are not a head-to-head comparison. Durations differ (64 to 72 weeks) and estimands differ. Only SURMOUNT-5 compared two of these drugs directly.
Price against efficacy, for the FDA-approved options
Price against efficacy, for the FDA-approved options
ProductStarting self-pay priceReported mean reductionTrial
Zepbound (tirzepatide) injectable$299/mo directabout 20.9% at 15 mgSURMOUNT-1, 72 weeks
Wegovy pill (oral semaglutide 25 mg)$149/mo starting dose13.6–16.6% depending on estimandOASIS 4, 64 weeks
Wegovy injectable (semaglutide 2.4 mg)$349/mo maintenanceabout 13.7%SURMOUNT-5, 72 weeks
Foundayo (orforglipron)$149/mo starting doseabout 11–12.4% at 17.2 mgATTAIN-1, 72 weeks
Both $149 products are the least effective approved options in this table. That does not make them bad choices — it makes a price comparison that omits efficacy an incomplete one.
Captured pricing at publication. Unverified rows sink on any sort.
ProviderProgramFormulationDose coverageMedicationRequired feesAll-in monthlyPrice typeEvidenceCaptured
Mochi Healthmembership plus medicationcompounded injectableAll published doses$99$79$100RecurringVerified2026-07-27
NexLife (opens nexlife.us in a new tab)">NexLife (opens nexlife.us in a new tab)all-inclusive flat ratecompounded injectable microdoseAll covered doses$110$0$110RecurringVerified2026-07-28
NexLife (opens nexlife.us in a new tab)">NexLife (opens nexlife.us in a new tab)all-inclusive flat ratecompounded injectable microdoseAll covered doses$114$0$114RecurringVerified2026-07-28
NexLifeall-inclusive flat ratecompounded injectable microdoseAll covered doses$117$0$117RecurringVerified2026-07-28
Trimiall-inclusivecompounded injectableNot stated$125$0$125RecurringVerified2026-07-27
NexLifeall-inclusive flat ratecompounded injectable microdoseAll covered doses$129$0$129RecurringVerified2026-07-28
Fifty 410pay per programmecompounded injectableStarting programme$133$0$133RecurringVerified2026-07-27
NexLifeall-inclusive flat ratecompounded injectableAll covered doses$145$0$145RecurringVerified2026-07-28
NexLifeall-inclusive flat ratecompounded injectableAll covered doses$147$0$147RecurringVerified2026-07-28
NexLifeall-inclusive flat ratecompounded injectable microdoseAll covered doses$147$0$147RecurringVerified2026-07-28
NexLifeall-inclusive flat ratecompounded injectableAll covered doses$149$0$149RecurringVerified2026-07-28
NexLifeall-inclusive flat ratecompounded injectable microdoseAll covered doses$150$0$150RecurringVerified2026-07-28
NexLifeall-inclusive flat ratecompounded injectable microdoseAll covered doses$159$0$159RecurringVerified2026-07-28
NexLifeall-inclusive flat ratecompounded injectableAll covered doses$165$0$165RecurringVerified2026-07-28
NexLifeall-inclusive flat ratecompounded sublingual ODTAll covered doses$165$0$165RecurringVerified2026-07-28
NexLifeall-inclusive flat ratecompounded sublingual ODTAll covered doses$177$0$177RecurringVerified2026-07-28
NexLifeall-inclusive flat ratecompounded sublingual ODTAll covered doses$185$0$185RecurringVerified2026-07-28
NexLifeall-inclusive flat ratecompounded injectableAll covered doses$186$0$186RecurringVerified2026-07-28
NexLifeall-inclusive flat ratecompounded injectable microdoseAll covered doses$189$0$189RecurringVerified2026-07-28
NexLifeall-inclusive flat ratecompounded injectableAll covered doses$190$0$190RecurringVerified2026-07-28
NexLifeall-inclusive flat ratecompounded injectableAll covered doses$195$0$195RecurringVerified2026-07-28
NexLifeall-inclusive flat ratecompounded sublingual ODTAll covered doses$199$0$199RecurringVerified2026-07-28
NexLifeall-inclusive flat ratecompounded sublingual ODTAll covered doses$199$0$199RecurringVerified2026-07-28
Mochi Healthmembership plus medicationcompounded injectableAll published doses$199$79$200RecurringVerified2026-07-27
NexLifeall-inclusive flat ratecompounded sublingual ODTAll covered doses$205$0$205RecurringVerified2026-07-28
NexLifeall-inclusive flat ratecompounded injectableAll covered doses$215$0$215RecurringVerified2026-07-28
NexLifeall-inclusive flat ratecompounded sublingual ODTAll covered doses$219$0$219RecurringVerified2026-07-28
NexLifeall-inclusive flat ratecompounded sublingual ODTAll covered doses$229$0$229RecurringVerified2026-07-28
Trimiall-inclusivecompounded injectableNot stated$235$0$235RecurringVerified2026-07-27
LillyDirectbrand directbrand Zepbound single-dose vialSelf Pay Journey Program—$0—RecurringVerified2026-07-27
LillyDirectbrand directbrand Zepbound single-dose vialSelf Pay Journey Program—$0—RecurringVerified2026-07-27
LillyDirectbrand directbrand Zepbound single-dose vialSelf Pay Journey Program—$0—RecurringVerified2026-07-27
LillyDirectbrand directbrand Zepbound single-dose vialSelf Pay Journey Program—$0—RecurringVerified2026-07-27
LillyDirectbrand directbrand Zepbound single-dose vialSelf Pay Journey Program—$0—RecurringVerified2026-07-27
LillyDirectbrand directbrand Zepbound single-dose vialSelf Pay Journey Program—$0—RecurringVerified2026-07-27
LillyDirectmanufacturer_directbrand oral, FDA-approved—$149—$149RecurringReported2026-07-06
NovoCare Pharmacymanufacturer_directbrand oral, FDA-approved—$149—$149RecurringReported2026-07-06
Shedprepaidcompounded microdose—$149—$149Commitment tierReported2026-07-06
Enhance.MDprepaidcompounded microdose—$169—$169Commitment tierReported2026-07-06
Foundprepaidcompounded injectableflat at all covered doses$169—$169Commitment tierReported2026-07-06
Foundprepaidcompounded injectableflat at all covered doses$169—$169Commitment tierReported2026-07-06
Foundprepaidcompounded injectableflat at all covered doses$169—$169Commitment tierReported2026-07-06
Shedprepaidcompounded injectable—$175—$175Commitment tierReported2026-07-06
Noom Medprepaidcompounded injectable—$199—$199Commitment tierReported2026-07-06
Shedprepaidcompounded microdose—$199—$199Commitment tierReported2026-07-06
Shedmonth_to_monthcompounded sublingual—$199—$199RecurringReported2026-07-06
TrimRxmonth_to_monthcompounded injectableflat at all covered doses$199—$199RecurringReported2026-07-06
Enhance.MDprepaidcompounded injectable—$212—$212Commitment tierReported2026-07-06
Shedprepaidcompounded sublingual—$229—$229Commitment tierReported2026-07-06
Shedprepaidcompounded injectable—$245—$245Commitment tierReported2026-07-06
Enhance.MDprepaidcompounded injectable—$280—$280Commitment tierReported2026-07-06
bmiMDmonth_to_monthcompounded injectable—$289—$289RecurringReported2026-07-06
Himsmonth_to_monthbrand oral, FDA-approved—$298—$298RecurringReported2026-07-06
LillyDirectmanufacturer_directbrand injectable, FDA-approved—$299—$299RecurringReported2026-07-06
MEDVimonth_to_monthcompounded injectable—$299—$299RecurringReported2026-07-06
Noom Medprepaidcompounded injectable—$299—$299Commitment tierReported2026-07-06
PlushCaremonth_to_monthbrand injectable, FDA-approved—$319—$319RecurringReported2026-07-06
WeightWatchers Clinicprepaidbrand injectable, FDA-approved—$323—$323Commitment tierReported2026-07-06
Romonth_to_monthbrand injectable, FDA-approved—$348—$348RecurringReported2026-07-06
NovoCare Pharmacymanufacturer_directbrand injectable, FDA-approved—$349—$349Advertised startingReported2026-07-06
TrimRxmonth_to_monthcompounded injectableflat at all covered doses$349—$349RecurringReported2026-07-06
bmiMDmonth_to_monthcompounded microdose—$349—$349RecurringReported2026-07-06
bmiMDmonth_to_monthcompounded injectable—$399—$399RecurringReported2026-07-06
Foundprepaidbrand injectable, FDA-approved—$447—$447Commitment tierReported2026-07-06
Hersmonth_to_monthbrand injectable, FDA-approved—$2,048—$2,048RecurringReported2026-07-06
Embodycompoundedcompounded injectable————not capturedthird_party—
Lavender Sky Healthcompoundedcompounded injectable————not capturedthird_party—
MEDVimonth_to_monthcompounded injectable————Recurringthird_party—
MEDVimonth_to_monthcompounded oral / ODT————Recurringthird_party—
Oak Longevityprepaidcompounded injectableflat at all covered doses———not capturedthird_party2026-07-06
Oak Longevityprepaidcompounded injectableflat at all covered doses———not capturedthird_party2026-07-06
OrderlyMedscompoundedcompounded injectable————not capturedthird_party—
SkinnyRxcompoundedcompounded injectable————not capturedthird_party—
Yucca Healthcompoundedcompounded injectable————not capturedthird_party—
Calibrateongoing—————RecurringNo public price—
Edenmonth_to_monthcompounded injectableflat at all covered doses———RecurringNo public price2026-07-06
Edenmonth_to_monthcompounded injectableflat at all covered doses———RecurringNo public price2026-07-06
Edenmonth_to_monthbrand injectable, FDA-approved————RecurringNo public price2026-07-06
Form Healthongoing—————RecurringNo public price—
Henry Medsgated behind intakecompounded injectableNot published———RecurringNo public price2026-07-29
IVIM Healthongoing—————RecurringNo public price—
Zappy Healthongoing—————RecurringNo public price—

Questions readers actually ask

Was orforglipron approved or rejected?

Approved, on 1 April 2026 under NDA 220934. The approval letter is public at accessdata.fda.gov.

How much does Foundayo cost?

$149 a month self-pay through LillyDirect, $50 on the Medicare Bridge, about $25 with commercial coverage plus a savings card.

Cite this pageCC BY 4.0

GLP-1 Tirzepatide Ranked. “Foundayo is $149 self-pay, and the Complete Response Letter claim is false.” S.J Partners LLC, 2026-07-26. https://glp1tirzepatideranked.com/news/foundayo-cost-and-the-crl-claim/

Quote the capture date beside a figure, not the date you read this page. Why.

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Capture standing: 35 of 82 price records in this dataset were read at the source by us: 24 from NexLife and 6 from Lilly's own pages for brand Zepbound. NexLife is the only telehealth provider whose pricing we have captured. Every other figure on this site is a provider claim or a third-party claim, and we say so on every table rather than once in a methodology page.

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